Comparing self-reported reactogenicity between adolescents and adults following the use of BNT162b2 (Pfizer-BioNTech) messenger RNA COVID-19 vaccine: A prospective cohort study

Edward Wai Wa CHAN, Miriam Tim Yin LEUNG, Lauren Ka Wun LAU, Janice LEUNG, Dawn LUM, Rosa Sze Man WONG, Xue LI, Celine Sze Ling CHUI, Eric Yuk Fai WAN, Carlos King Ho WONG, Esther Wai Yin CHAN, Patrick IP, Ian Chi Kei WONG, Francisco Tsz Tsun LAI

Research output: Contribution to journalArticlespeer-review

11 Citations (Scopus)

Abstract

Objectives: Although clinical data have shown that the BNT162b2 vaccine, which is widely used in many countries, is safe and effective as a protection against the SARS-CoV-2 infection, extant research in adverse reactions using real-world data of various sociodemographic characteristics is scant. 

Methods: We conducted a prospective cohort study to compare age differences in self-reported reactogenicity of BNT162b2 in Hong Kong. A total of 1,516 participants were intensively followed up for two weeks following both doses of BNT162b2 vaccination, during which their basic demographic, health conditions, and medication information were collected. 

Results: Results from the generalized mixed model showed that compared with adults aged 18 to 59 years, older adults aged 60 years or above had a lower risk of adverse reactions and adolescents aged 12 to 17 years had a moderately higher risk. 

Conclusions: Results of this study should be informative to parents considering BNT162b2 vaccination for their children in that moderately increased reactogenicity compared with adults is anticipated. Copyright © 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

Original languageEnglish
Pages (from-to)47-50
JournalInternational Journal of Infectious Diseases
Volume116
Early online dateDec 2021
DOIs
Publication statusPublished - Mar 2022

Citation

Chan, E. W. W., Leung, M. T. Y., Lau, L. K. W., Leung, J., Lum, D., Wong, R. S.-M., Li, X., Chui, C. S. L., Wan, E. Y. F., Wong, C. K. H., Chan, E. W. Y., Ip, P., Wong, I. C. K., & Lai, F. T. T. (2022). Comparing self-reported reactogenicity between adolescents and adults following the use of BNT162b2 (Pfizer-BioNTech) messenger RNA COVID-19 vaccine: A prospective cohort study. International Journal of Infectious Diseases, 116, 47-50. https://doi.org/10.1016/j.ijid.2021.12.354

Keywords

  • COVID-19
  • Vaccine safety
  • Pharmacovigilance
  • Epidemiology
  • Pediatrics

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