Comparing immune responses to inactivated vaccines against SARS-CoV-2 between people living with HIV and HIV-negative individuals: A cross-sectional study in China

Xiaojie HUANG, Ying YAN, Bin SU, Dong XIAO, Maohe YU, Xia JIN, Junyi DUAN, Xiangjun ZHANG, Shimin ZHENG, Yuan Josephine FANG, Tong ZHANG, Weiming TANG, Lunan WANG, Zixin WANG, Junjie XU

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6 Citations (Scopus)

Abstract

This study compared the immunogenicity of inactivated SARS-CoV-2 vaccines between people living with HIV (PLWH) and HIV-negative individuals. We recruited 120 PLWH and 53 HIV-negative individuals aged 18–59 years who had received an inactivated SARS-CoV-2 vaccine in two Chinese cities between April and June 2021. Blood samples were tested for immunogenicity of the inactivated SARS-CoV-2 vaccines. The prevalence and severity of adverse events associated with SARS-CoV-2 vaccines were similar between PLWH and HIV-negative individuals. The seropositivity of neutralizing activity against authentic SARS-CoV-2, of the total amount of antibody (total antibody) and of S-IgG were 71.3%, 81.9%, and 92.6%, respectively, among fully vaccinated PLWH. Among all participants, PLWH had lower neutralizing activity, total antibody, S-IgG, and T-cell-specific immune response levels, compared to HIV-negative individuals, after controlling for types of vaccine, time interval between first and second dose, time after receiving the second dose, and sociodemographic factors. PLWH with a longer interval since HIV diagnosis, who received their second dose 15–28 days prior to study commencement, and who had an interval of ≥21 days between first and second dose had higher neutralizing activity levels. The immunogenicity of the inactivated SARS-CoV-2 vaccines was lower among PLWH as compared to HIV-negative individuals. Vaccination guideline specific for PLWH should be developed. Copyright © 2022 by the authors.
Original languageEnglish
Article number277
JournalViruses
Volume14
Issue number2
Early online date28 Jan 2022
DOIs
Publication statusPublished - Feb 2022

Citation

Huang, X., Yan, Y., Su, B., Xiao, D., Yu, M., Jin, X., . . . Xu, J. (2022). Comparing immune responses to inactivated vaccines against SARS-CoV-2 between people living with HIV and HIV-negative individuals: A cross-sectional study in China. Viruses, 14(2). Retrieved from https://doi.org/10.3390/v14020277

Keywords

  • People living with HIV
  • Inactivated SARS-CoV-2 vaccines
  • Self-reported adverse events
  • Neutralizing activity responses against authentic SARS-CoV-2
  • Total antibody specific to SARS-CoV-2
  • SARS-CoV-2 IgG antibody
  • Antigen-specific T-cell immune response

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