Cognitive impairment in aneurysmal subarachnoid hemorrhage patients with delayed cerebral infarction: Prevalence and pattern

Alberto Chi Ho CHU, Kwok Chu George WONG, Sandy Wai LAM, Adrian WONG, Ka Ying Karine NGAI, Wai Sang POON, Chung Tong Vincent MOK

Research output: Chapter in Book/Report/Conference proceedingChapters

5 Citations (Scopus)

Abstract

Background: Cognitive deficits commonly occur after aneurysmal subarachnoid hemorrhage (aSAH) and clinical understanding is important for treatment and rehabilitation. Delayed cerebral infarction was shown to be related to poor outcome. Data on delayed cerebral infarction-related cognitive impairment were lacking. Objective: We investigated the prevalence and pattern of delayed cerebral infarction-associated cognitive impairment. Methods: We carried out a prospective observational and diagnostic accuracy study in Hong Kong in patients aged 21–75 years with aSAH who had been admitted within 96 h of ictus. The domain-specific neuropsychological assessment battery at 1 year after ictus was used for cognitive assessments. A cognitive domain deficit was defined as a cognitive domain z score less than −1.65 (below the fifth percentile). Cognitive impairment was defined by two or more cognitive domain deficits. The current study is registered at ClinicalTrials.gov of the U.S. National Institutes of Health (NCT01038193). Results: One hundred and twenty aSAH patients were recruited. Patients with delayed cerebral infarction (DCI) have cognitive impairment more frequently (22 % vs 11 %; odds ratio: 2.2, 0.6 to 7.8, p = 0.192). Cognitive domain deficits commonly affected in aSAH patients with delayed cerebral infarction were verbal memory, language, and visuospatial memory and skill domains, and were relatively uncommon in aSAH patients without delayed cerebral infarction. Conclusion: In patients with aSAH, delayed cerebral infarction was associated with a specific pattern of cognitive domain deficits. The pathophysiology should be further investigated. Copyright © 2015 Springer International Publishing Switzerland.
Original languageEnglish
Title of host publicationNeurovascular events after subarachnoid hemorrhage: Towards experimental and clinical standardization
EditorsJavier FANDINO, Serge MARBACHER, Ali-Reza FATHI, Carl MUROI, Emanuela KELLER
Place of PublicationSwitzerland
PublisherSpringer International Publishing
Pages303-306
ISBN (Electronic)9783319049816
ISBN (Print)9783319049809
DOIs
Publication statusPublished - 2015

Citation

Chu, A. C. H., Wong, G. K. C., Lam, S. W., Wong, A., Ngai, K., Poon, W. S., et al. (2015). Cognitive impairment in aneurysmal subarachnoid hemorrhage patients with delayed cerebral infarction: Prevalence and pattern. In J. Fandino, S. Marbacher, A.-R. Fathi, C. Muroi, E. Keller (Eds.), Neurovascular events after subarachnoid hemorrhage: Towards experimental and clinical standardization (pp.303-306). Switzerland: Springer International Publishing.

Keywords

  • Aneurysm
  • Cognitive impairment
  • Stroke
  • Subarachnoid hemorrhage

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