Ceftriaxone ameliorates motor deficits and protects dopaminergic neurons in 6-hydroxydopamine-lesioned rats

T. C. H. LEUNG, C. N. P. LUI, L. W. CHEN, W. H. YUNG, Y. S. CHAN, Kin Lam Ken YUNG

Research output: Contribution to journalArticlespeer-review

64 Citations (Scopus)

Abstract

Parkinson's disease is caused by the degeneration of dopaminergic neurons in substantia nigra. There is no current promising treatment for neuroprotection of dopaminergic neurons. Ceftriaxone is a beta-lactam antibiotic and has been reported to offer neuroprotective effects (Rothstein, J.-D., Patel, S., Regan, M.-R., Haenggeli, C., Huang, Y.-H., Bergles, D.-E., Jin, L., Dykes, H.-M., Vidensky, S., Chung, D.-S., Toan, S.-V., Bruijn, L.-I., Su, Z.-Z., Gupta, P., and Fisher, P.-B. (2005) Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression Nature433, 73-77). In the present study, efficacy of ceftriaxone in neuroprotection of dopaminergic neurons and amelioration of motor deficits in a rat model of Parkinson's disease were investigated. Ceftriaxone was administrated in 6-hydroxydopamine-lesioned rats. Using behavioral tests, grip strength and numbers of apomorphine-induced contralateral rotation were declined in the ceftriaxone-treated group. More importantly, cell death of dopaminergic neurons was found to decrease. In addition, both the protein expression and immunoreactivity for GLT-1 were up-regulated. The present results strongly indicate that ceftriaxone is a potential agent in the treatment of Parkinson's disease. Copyright © 2011 American Chemical Society.

Original languageEnglish
Pages (from-to)22-30
JournalACS Chemical Neuroscience
Volume3
Issue number1
Early online dateOct 2011
DOIs
Publication statusPublished - 2012

Citation

Leung, T. C. H., Lui, C. N. P., Chen, L. W., Yung, W. H., Chan, Y. S., & Yung, K. K. L. (2012). Ceftriaxone ameliorates motor deficits and protects dopaminergic neurons in 6-hydroxydopamine-lesioned rats. ACS Chemical Neuroscience, 3(1), 22-30. https://doi.org/10.1021/cn200072h

Keywords

  • Animal model of Parkinson’s disease
  • Degeneration of dopaminergic neurons
  • Antibiotic
  • Ceftriaxone
  • Glutamate transporter
  • Glutamate transporter subtype 1
  • Basal ganglia

Fingerprint

Dive into the research topics of 'Ceftriaxone ameliorates motor deficits and protects dopaminergic neurons in 6-hydroxydopamine-lesioned rats'. Together they form a unique fingerprint.