Can the neural–cortisol association be moderated by experience-induced changes in awareness?

Kwok Wai LAU, Mei Kei LEUNG, Chetwyn Chi Hin CHAN, Samuel S. Y. WONG, Tatia Mei Chun LEE

Research output: Contribution to journalArticles

8 Citations (Scopus)

Abstract

Cortisol homeostasis is important for cognitive and affective functions that depend on cortisol-sensitive brain regions including the hippocampus and prefrontal cortex. Recent studies have shown that training induces changes in the brain. We report the findings of a longitudinal study that verified the moderation effect of experience-induced changes in awareness on the neural–cortisol association in cortisol-sensitive brain regions. These findings provide the first piece of evidence that planned behavioral experience can moderate the neural–cortisol association. A range of changes in awareness was achieved in a sample of 21 Chinese participants, divided into two groups: Awareness-based compassion meditation (ABCM) (n = 10) and relaxation (n = 11). We observed that changes in awareness were significant moderators of hippocampal–cortisol changes. Furthermore, a significant negative association between changes in plasma cortisol level and the resting-state synchrony of the right hippocampal and insular-frontal-operculum regions was observed. These novel findings shed light on the inter-relationships between changes in hippocampal–cortisol levels and changes in awareness and preliminarily identify the neural underpinnings of interventions for cortisol-related abnormal functioning for further study. Copyright © 2015 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Original languageEnglish
Article number16620
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 2015

Citation

Lau, W. K. W., Leung, M.-K., Chan, C. C. H., Wong, S. S. Y., & Lee, T. M. C. (2015). Can the neural–cortisol association be moderated by experience-induced changes in awareness? Scientific Reports, 5. Retrieved from http://dx.doi.org/10.1038/srep16620

Keywords

  • Cooperation
  • Empathy

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