Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl Phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae

Qiangwei WANG, Nelson Lok-Shun LAI, Xianfeng WANG, Yongyong GUO, Paul Kwan-Sing LAM, Chung Wah James LAM, Bingsheng ZHOU

Research output: Contribution to journalArticles

103 Citations (Scopus)

Abstract

Organophosphate flame retardants are emerging environmental contaminants, although knowledge of their health risks is limited. Here, thyroid hormone homeostasis and neuronal development was studied in the progeny of adult zebrafish exposed to tris(1,3-dichloro-2-propyl) phosphate (TDCPP). Adult zebrafish were exposed to TDCPP (0, 4, 20, and 100 μg/L) for 3 months. Increased generation of reactive oxygen species and reduced survival rates was observed in exposed F1 larvae. We also observed a significant decrease in plasma thyroxine and 3,5,3′-triiodothyronine levels in F0 females and F1 eggs/larvae. The mRNA and protein expression of factors associated with neuronal development (e.g., α1-tubulin, myelin basic protein, and synapsin IIa) were significantly downregulated in exposed F1 larvae, as was the level of the neurotransmitters dopamine, serotonin, gamma amino butyric acid, and histamine. Larval locomotion was significantly decreased in exposed fish, but there was no effect on acetylcholinesterase activity. Bioconcentration of TDCPP was observed in F0 fish. TDCPP was also detected in F1 eggs following parental exposure, indicating maternal transfer of this compound. This study uniquely shows that TDCPP can be transferred to the offspring of exposed adults, causing thyroid endocrine disruption and developmental neurotoxicity. Copyright © 2015 American Chemical Society.
Original languageEnglish
Pages (from-to)5123-5132
JournalEnvironmental Science & Technology
Volume49
Issue number8
Early online date31 Mar 2015
DOIs
Publication statusPublished - 21 Apr 2015

Citation

Wang, Q., Lai, N. L.-S., Wang, X., Guo, Y., Lam, P. K.-S., Lam, J. C. W., & Zhou, B. (2015). Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl Phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae. Environmental Science & Technology, 49, 5123-5132. doi: 10.1021/acs.est.5b00558.

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