Bioaccumulation, tissue distribution and joint toxicity of erythromycin and cadmium in Chinese mitten crab (Eriocheir sinensis)

Lin CHENG, Jun Liang ZHOU, Jinping CHENG

Research output: Contribution to journalArticlespeer-review

14 Citations (Scopus)

Abstract

The bioaccumulation of erythromycin (ETM) and cadmium (Cd) in Chinese mitten crab (Eriocheir sinensis) and subsequent toxicity on pathological changes and enzymatic activities were investigated during 21-day exposure to ETM, Cd, and Cd + ETM mixture. The bioaccumulation of Cd and ETM residues in crab tissues decreased as gill > hepatopancreas > muscle > ovary, with higher Cd bioaccumulation than ETM. The highest Cd bioaccumulation in crab reached 1.15 mg/g dry weight in gill and 461.29 μg/g in hepatopancreas, on the 14th day of Cd treatment. Cd exposure promoted the bioaccumulation of ETM in four tissues. ETM exposure caused tubular vacuolization in epithelial and edema and degeneration of hepatic ducts in hepatopancreas, and disconnected gill epithelial layer and indistinctly cellular structure in gill. During Cd exposure, mitochondria acted as a main biomarker to identify the damage, including reduced and swollen mitochondria, and broken mitochondrial structure. Moreover, Chinese mitten crab showed defence capability against ETM and Cd exposure by physiological adjustment of metabolic enzymes glutathione S-transferase activity. Copyright © 2018 Elsevier Ltd. 
Original languageEnglish
Pages (from-to)267-278
JournalChemosphere
Volume210
Early online date03 Jul 2018
DOIs
Publication statusPublished - Nov 2018

Citation

Cheng, L., Zhou, J. L., & Cheng, J. (2018). Bioaccumulation, tissue distribution and joint toxicity of erythromycin and cadmium in Chinese mitten crab (Eriocheir sinensis). Chemosphere, 210, 267-278. doi: 10.1016/j.chemosphere.2018.07.005

Keywords

  • Erythromycin
  • Cadmium
  • Bioaccumulation
  • Joint toxicity
  • Pathological observation
  • Metabolic enzymes

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