Association of prenatal exposure to organochlorine pesticides and birth size

Jing FANG, Hongxiu LIU, Hongzhi ZHAO, Ming Hung WONG, Shunqing XU, Zongwei CAI

Research output: Contribution to journalArticle

Abstract

There has been substantial evidence showing the adverse effects of organochlorine pesticide (OCP) exposure on human, but studies focused on the prenatal exposure effects at low OCP levels on infant birth size were scarce and controversial. In this study, cord serum samples were collected at the delivery from 1028 pairs of mothers and newborns in Wuhan, China and investigated the associations of prenatal exposure to OCPs and birth size. The prenatal exposure of hexachlorocyclohexane isomers (HCHs), p,p′-dichlorodiphenyltrichloroethane (p,p′-DDT) and its metabolites were analyzed. The associations between birth size and prenatal OCP exposure were examined by multiple linear regressions. A sex-specific relationship between the OCP exposure and birth size was observed. β-HCH was negatively associated with birth weight and ponderal index for boys [adjusted β = −28.61; 95% confidence interval (CI): −54.84, −4.37 and adjusted β = −0.17; 95% CI: −0.32, −0.01, respectively], whilst no significant associations with prenatal exposure of OCPs were found among girls. The inverse association of prenatal exposure to low levels of β-HCH was shown sex-specific difference, which was only observed significantly in boys. The findings strengthened the evidence that the fetal development was influenced by prenatal exposure to certain OCPs and the effects might be different in the newborn sex. Copyright © 2018 Published by Elsevier B.V.
Original languageEnglish
Pages (from-to)678-683
JournalScience of the Total Environment
Volume654
Early online dateOct 2018
DOIs
Publication statusPublished - Mar 2019

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Pesticides
HCH
Lindane
Metabolites
Linear regression
Isomers
confidence interval
organochlorine pesticide
exposure
DDT
serum
metabolite

Bibliographical note

Fang, J., Liu, H., Zhao, H., Wong, M., Xu, S., & Cai, Z. (2019). Association of prenatal exposure to organochlorine pesticides and birth size. Science of The Total Environment, 654, 678-683. doi: 10.1016/j.scitotenv.2018.10.384

Keywords

  • Organochlorines pesticides
  • Cord serum
  • Birth size