Assessment of risk to humans of bisphenol A in marine and freshwater fish from Pearl River Delta, China

Xi WEI, Yeqing HUANG, Ming Hung WONG, John P. GIESY, Chris K. C. WONG

Research output: Contribution to journalArticle

46 Citations (Scopus)


Bisphenol A (BPA) is a high production-volume chemical used in the manufacture of a wide variety of consumer products. However it is also a ubiquitous contaminant that can interfere with endocrine systems of wildlife and humans. China is the " world factory" and the Pearl River Delta is the major manufacturing center and is consequently polluted. Concentrations of BPA in meats of marketable fish had not been previously reported for this region. In the study upon which we report here concentrations of BPA were determined in 20 common species of freshwater and marine fish, collected from markets in Hong Kong, SAR, China. A comprehensive analytical method based on SPE extraction and liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) was developed, validated and applied. The method limit of detection (LOD) and limit of quantification (LOQ) were 0.5 and 1.25 ng g-1 dw, respectively. BPA was detected in 19 species of fish at concentrations, ranging from 0.5 to 2.0 ng g-1 ww. Average daily BPA intake per person ranged from 1.1 × 10ng d-1 for marine fish and 2.2 × 10ng d-1 for freshwater fish. Concentrations of BPA in fish from Hong Kong markets unlikely would be causing adverse population-level effects in humans. Copyright © 2011 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)122-128
Issue number1
Publication statusPublished - Sep 2011


Fresh Water
Hong Kong
endocrine system
Electrospray ionization
Endocrine System
Consumer products
Electrospray Ionization Mass Spectrometry
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography

Bibliographical note

Wei, X., Huang, Y., Wong, M. H., Giesy, J. P., & Wong, C. K. C. (2011). Assessment of risk to humans of bisphenol A in marine and freshwater fish from Pearl River Delta, China. Chemosphere, 85(1), 122-128. doi: 10.1016/j.chemosphere.2011.05.038


  • Fish pollution
  • Bisphenol A
  • LC/MS/MS
  • Health