Aquatic hypoxia is an endocrine disruptor and impairs fish reproduction

Shiu Sun Rudolf WU, Bing Sheng ZHOU, David J. RANDALL, Norman Y. S. WOO, Paul K. S. LAM

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299 Citations (Scopus)


There is increasing concern that certain chemicals in the aquatic environment can disrupt endocrine systems, leading to reproductive impairment and threatening survival of wild populations of invertebrates, fish, bird, reptiles, and wildlife. For the first time, we report that hypoxia is also an endocrine disruptor and poses a significant threat to the reproduction and hence sustainability of fish populations. Serum levels of testosterone, estradiol, and triiodothyronine significantly decreased in carp (Cyprinus carpio) upon chronic exposure to hypoxia. These hormonal changes were associated with retarded gonadal development in both male and female carp, reduced spawning success, sperm motility, fertilization success, hatching rate, and larval survival, indicating that adverse effects of hypoxia on reproductive performance resulted from endocrine disruption. Since aquatic hypoxia commonly occurs over thousands of square kilometers in aquatic systems worldwide, our results imply that endocrine disruption and reproductive impairment in fish may be a widespread environmental problem. Copyright © 2003 American Chemical Society.

Original languageEnglish
Pages (from-to)1137-1141
JournalEnvironmental Science and Technology
Issue number6
Publication statusPublished - Mar 2003


Wu, R. S. S., Zhou, B. S., Randall, D. J., Woo, N. Y. S., & Lam, P. K. S. (2003). Aquatic hypoxia is an endocrine disruptor and impairs fish reproduction. Environmental Science & Technology, 37(6), 1137-1141. doi: 10.1021/es0258327


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