Anomalous static and dynamic functional connectivity of amygdala subregions in individuals with high trait anxiety

Chanyu WANG, You WANG, Kwok Wai LAU, Xinhua WEI, Xiangang FENG, Chichen ZHANG, Yingjun LIU, Ruiwang HUANG, Ruibin ZHANG

Research output: Contribution to journalArticlespeer-review

1 Citation (Scopus)

Abstract

Background: Trait anxiety is considered a susceptible factor for stress-related disorders, and is characterized by abnormal brain activity and connectivity in the regions related to emotional processing (e.g., the amygdala). However, only a few studies have examined the static and dynamic changes of functional connectivity in trait anxiety.
Method: We compared the resting-state static and dynamic functional connectivity (sFC/dFC) in individuals with high trait anxiety (HTA, n = 257) and low trait anxiety (LTA, n = 264) using bilateral amygdala subregions as the seeds, that is, the centromedial amygdala (CMA), basolateral amygdala (BLA), and superficial amygdala (SFA).
Results: The CMA, BLA, and SFA all showed reduced sFC with the executive control network (ECN) and anomalous dFC with the default mode network (DMN) in individuals with HTA. The CMA only showed reduced sFC with the ECN and reduced dFC with the DMN in individuals with HTA. The BLA showed reduced sFC with the salience network (mainly in the anterior and median cingulate), and increased dFC between the BLA and the DMN in individuals with HTA compared to those with LTA. Notably, HTA showed widespread anomalous functional connectivity in the SFA, including the visual network, mainly in the calcarine fissure, limbic system (olfactory cortex), and basal ganglia (putamen).
Conclusion: The anomalous sFC and dFC in individuals with HTA may reflect altered mechanisms in prefrontal control, salient stimuli processing, and amygdaloidal responsivity to potential threats, leading to alterations in associative, attentional, interpretative, and regulating processes that sustain a threat-related processing bias in HTA individuals. Copyright © 2021 Wiley Periodicals LLC.
Original languageEnglish
Pages (from-to)860-873
JournalDepression and Anxiety
Volume38
Issue number8
Early online dateJul 2021
DOIs
Publication statusPublished - Aug 2021

Citation

Wang, C., Wang, Y., Lau, W. K. W., Wei, X., Feng, X., Zhang, C., . . . Zhang, R. (2021). Anomalous static and dynamic functional connectivity of amygdala subregions in individuals with high trait anxiety. Depression and Anxiety, 38(8), 860-873. doi: 10.1002/da.23195

Keywords

  • Emotion regulation
  • Functional connectivity
  • Trait anxiety

Fingerprint

Dive into the research topics of 'Anomalous static and dynamic functional connectivity of amygdala subregions in individuals with high trait anxiety'. Together they form a unique fingerprint.