Angiosuppressive properties of marine-derived compounds: A mini review

Patrick Ying Kit YUE, H. M. LEUNG, Jing Adela LI, Tracy N. C. CHAN, T. S. LUM, Y. L. CHUNG, Yik Hei SUNG, Ming Hung WONG, S. Y. Kelvin LEUNG, Eddy Y. ZENG

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2 Citations (Scopus)

Abstract

Angiogenesis, formation of new blood vessels from preexisting one, is a critical step of tumorgenesis of solid tumors. Therefore, antiangiogenic therapy is one of the promising approaches to control tumor growth. In the past 20 years, a lot of compounds have been tested for their antiangiogenic properties. Bevacizumab, Avastin®, the first antiangiogenic drug approved by the US FDA, has been widely used in clinic for treating cancer. Indeed, many synthetic compounds are highly toxic and exert side effects even though they are effective in inhibiting neovessel formation and cancer cell growth. Using natural compounds or their derivatives is one of the ways to solve these problems. Sinomenine and ginsenosides are common antiangiogenic and anticancer compounds that are extracted from herbal medicines. Recent findings suggested that marine algae-derived natural pigments also possess similar activities. It has been reported that fucoxanthin from Undaria pinnatifida, Siphonaxanthin from Codium fragile, can inhibit angiogenesis and cancer growth effectively. In conclusion, natural compounds derived from marine algae could provide a novel and safe source for new drug development in anticancer and antiangiogenic properties in the future. Copyright © 2015 Springer-Verlag Berlin Heidelberg.
Original languageEnglish
Pages (from-to)8990-9001
JournalEnvironmental Science and Pollution Research
Volume24
Issue number10
Early online dateOct 2015
DOIs
Publication statusPublished - Apr 2017

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Algae
Tumors
cancer
Ginsenosides
tumor
Poisons
Blood vessels
Cell growth
alga
drug development
Pigments
Pharmaceutical Preparations
Neoplasms
Derivatives
Undaria
Growth
pigment
drug
vessel
blood

Citation

Yue, P. Y. K., Leung, H. M., Li, A. J., Chan, T. N. C., Lum, T. S., Chung, Y. L., et al. (2017). Angiosuppressive properties of marine-derived compounds: A mini review. Environmental Science and Pollution Research, 24(10), 8990-9001.

Keywords

  • Angiogenesis
  • Marine-derived compound
  • Angiosuppression