Ambient air PM2.5 exposure induces heart injury and cardiac hypertrophy in rats through regulation of miR-208a/b, α/β-MHC, and GATA4

Lirong BAI, Yufei ZHAO, Lifang ZHAO, Mei ZHANG, Zongwei CAI, Kin Lam Ken YUNG, Chuan DONG, Ruijin LI

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9 Citations (Scopus)

Abstract

Ambient air fine particulate matter (PM2.5) may increase cardiovascular disease risks. In this study, we investigated the miR-208/GATA4/myosin heavy chain (MHC) regulation mechanisms on cardiac injury in rats after PM2.5 exposure via an animal inhalation device. The results showed that PM2.5 exposure for 2 months caused pathological heart injury, reduced nucleus-cytoplasm ratio, and increased the levels of CK-MB and cTnI, showing cardiac hypertrophy. Oxidative stress and inflammatory responses were also observed in rats’ hearts exposed to PM2.5. Of note, PM2.5 exposure for 2-month significantly elevated GATA4 and β-MHC mRNA and protein expression compared with the corresponding controls, along with the high-expression of miR-208b. The ratios of β-MHC/α-MHC expression induced by PM2.5 were remarkably raised in comparison to their controls. It suggested that the up-regulation of miR-208b/β-MHC and GATA4 and the conversion from α-MHC to β-MHC may be the important causes of cardiac hypertrophy in rats incurred by PM2.5. Copyright © 2021 Elsevier B.V. All rights reserved.

Original languageEnglish
Article number103653
JournalEnvironmental Toxicology and Pharmacology
Volume85
Early online dateMar 2021
DOIs
Publication statusPublished - Jul 2021

Citation

Bai, L., Zhao, Y., Zhao, L., Zhang, M., Cai, Z., Yung, K. K. L., Dong, C., & Li, R. (2021). Ambient air PM₂.₅ exposure induces heart injury and cardiac hypertrophy in rats through regulation of miR-208a/b, α/β-MHC, and GATA4. Environmental Toxicology and Pharmacology, 85, Article 103653. https://doi.org/10.1016/j.etap.2021.103653

Keywords

  • PM₂.₅
  • Heart injury
  • Rats
  • miR-208a/b
  • GATA4
  • α/β-MHC

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