Age-related differences in response regulation as revealed by functional MRI

Tatia M.C. LEE, John X. ZHANG, Che Hin Chetwyn CHAN, Kenneth S.L. YUEN, L.W. CHU, Raymond T.F. CHEUNG, Y.S. CHAN, Peter T. FOX, Jia-Hong GAO

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24 Citations (Scopus)


This fMRI study studied age-related differences in neural activities during response regulation. Twenty-one male participants from two age groups, a younger group and an older group (mean ages: 29.9 and 65.2 years, respectively), were scanned while performing a task with response compatibility manipulation. They were presented with a sequence of arrowheads that pointed either upward or downward. In the “Response Compatible” condition, they were required to press an up or a down button consistent with the direction of the arrowhead. In the “Response Incompatible” condition, they were required to press the button opposite to the arrowhead direction so that an upward arrow should elicit a down response, and vice versa. Findings showed age-related differences in response regulation in several brain regions, including the right frontal, the right cingulate, and the left inferior parietal cortexes. The findings suggested a higher level of neural activity in the right prefrontal and left inferior parietal regions during response regulation for the older adults than for the younger adults. Copyright © 2006 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)171-176
JournalBrain Research
Issue number1
Early online dateFeb 2006
Publication statusPublished - Mar 2006


Lee, T. M. C., Zhang, J. X., Chan, C. C. H., Yuen, K. S. L., Chu, L. W., Cheung, R. T. F., . . . Gao, J.-H. (2006). Age-related differences in response regulation as revealed by functional MRI. Brain Research, 1076(1), 171-176. doi: 10.1016/j.brainres.2005.12.124


  • Habitual response
  • Response regulation
  • Inhibition
  • Ageing
  • Functional magnetic resonance imaging


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