Accumulation of perfluorobutane sulfonate (PFBS) and impairment of visual function in the eyes of marine medaka after a life-cycle exposure

Lianguo CHEN, Mirabelle M. P. TSUI, Qipeng SHI, Chenyan HU, Qi WANG, Bingsheng ZHOU, Paul K. S. LAM, Chung Wah James LAM

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Abstract

As an alternative to perfluorooctane sulfonate (PFOS), increasing usage of perfluorobutane sulfonate (PFBS) has led to ubiquitous presence in the environment. PFBS is also shown to potently disrupt the thyroid endocrine system. Considering the regulation of thyroid hormones in visual development, PFBS is likely to adversely affect the development and function of visual systems, which is a sensitive target of environmental pollutants. Therefore, the present study exposed marine medaka embryos to environmentally realistic concentrations of PFBS (0, 1.0, 2.9 and 9.5 μg/L) for an entire life-cycle. After exposure until sexual maturity, eyes of adult medaka were dissected to directly investigate the ocular accumulation and toxicity of PFBS. For the first time, substantial accumulation of an environmental pollutant (i.e., PFBS) was observed in the eye tissue. PFBS exposure was also found to impair the visual development and function in a sex-dependent manner. In female medaka, weight of eyes was significantly decreased, while content of water was increased, probably resulting in higher intraocular pressure. Multiple neural signaling processes were also disturbed by PFBS life-cycle exposure, including cholinergic, glutamatergic, GABAergic and monoaminergic systems. Increased levels of norepinephrine and epinephrine neurotransmitters may adaptively decrease the intraocular hypertension in female eyes. In addition, proteomic profiling identified the visual proteins of differential expressions (e.g., beta and gamma crystallins, arrestin and lumican), which were significantly associated with visual perception and motor activity of eyes. Overall, this study found that PFBS was able to accumulate in the eyes and induce ocular toxicities. The susceptibility and sex-specific responses of visual systems to environmental pollutants warrants more works for a comprehensive risk assessment. Copyright © 2018 Elsevier B.V. All rights reserved.
LanguageEnglish
Pages1-10
JournalAquatic Toxicology
Volume201
Early online dateMay 2018
DOIs
Publication statusPublished - 2018

Fingerprint

Oryzias
sulfonates
Vision Disorders
sulfonate
Life Cycle Stages
life cycle (organisms)
life cycle
eyes
Environmental Pollutants
pollutants
pollutant
beta-Crystallins
gamma-Crystallins
arrestins
toxicity
crystallins
Arrestin
perfluorobutane
exposure
endocrine system

Citation

Chen, L., Tsui, M. M. P., Shi, Q., Hu, C., Wang, Q., Zhou, B., . . . Lam, J. C. W. (2018). Accumulation of perfluorobutane sulfonate (PFBS) and impairment of visual function in the eyes of marine medaka after a life-cycle exposure. Aquatic Toxicology, 201, 1-10. doi: 10.1016/j.aquatox.2018.05.018

Keywords

  • PFBS
  • Life-cycle exposure
  • Marine medaka
  • Bioaccumulation
  • Visual function