Abstract
Objective: To examine the spontaneous blink rate over a 3-year period and its clinical and cognitive correlates among patients with first-episode schizophrenia.
Methods: This study prospectively followed 93 patients with first-episode schizophrenia, schizophreniform and schizoaffective disorders for 3 years. Patients were longitudinally assessed for blink rate, their positive and negative symptoms, and a range of cognitive features including verbal fluency, verbal memory, visual memory, and the Wisconsin Card Sorting Test performance.
Results: When compared with a matched control group, there was a significantly higher blink rate at their 3-year follow-up but not at initial presentation. The increase in blink rate over time correlated positively with the number of relapses. It also correlated with logical memory, verbal fluency, categories completed, and perseverative errors in the Wisconsin Card Sorting Test. The increased blink rate also correlated with pre-morbid schizoid and schizotypal traits. All these correlations were statistically significant.
Conclusion: The change in the blink rate over time may reflect underlying involvement of the dopaminergic system in mediating relapse and cognitive functions.
目的:檢視首發精神分裂症患者3年內其自發性眨眼率和有關臨床和認知功能的相互關係。
方法:研究以3年時間跟進93名首發精神分裂症、類精神分裂症或分裂情感性疾患者,追蹤評估他們的眨眼率、正面和負面徵狀和各種認知行為,包括口頭流暢、口頭記憶、視覺記憶和威斯康卡片排序測試。
結果:與對照組比較,患者3年後的眨眼率較入院時顯著上升;這跟病情復發次數顯著相關,也與邏輯記憶、口頭流暢、類別完成,以及威斯康卡片排序測試的持續性錯誤呈相關性。眨眼率的增加也與病前的類精神分裂人格異常和分裂性人格障礙特徵相關。以上相關性都是顯著的。
結論:多巴胺系統的運作或影響病情復發和認知功能,從而改變患者的眨眼率。 Copyright © 2010 Hong Kong College of Psychiatrists.
Methods: This study prospectively followed 93 patients with first-episode schizophrenia, schizophreniform and schizoaffective disorders for 3 years. Patients were longitudinally assessed for blink rate, their positive and negative symptoms, and a range of cognitive features including verbal fluency, verbal memory, visual memory, and the Wisconsin Card Sorting Test performance.
Results: When compared with a matched control group, there was a significantly higher blink rate at their 3-year follow-up but not at initial presentation. The increase in blink rate over time correlated positively with the number of relapses. It also correlated with logical memory, verbal fluency, categories completed, and perseverative errors in the Wisconsin Card Sorting Test. The increased blink rate also correlated with pre-morbid schizoid and schizotypal traits. All these correlations were statistically significant.
Conclusion: The change in the blink rate over time may reflect underlying involvement of the dopaminergic system in mediating relapse and cognitive functions.
目的:檢視首發精神分裂症患者3年內其自發性眨眼率和有關臨床和認知功能的相互關係。
方法:研究以3年時間跟進93名首發精神分裂症、類精神分裂症或分裂情感性疾患者,追蹤評估他們的眨眼率、正面和負面徵狀和各種認知行為,包括口頭流暢、口頭記憶、視覺記憶和威斯康卡片排序測試。
結果:與對照組比較,患者3年後的眨眼率較入院時顯著上升;這跟病情復發次數顯著相關,也與邏輯記憶、口頭流暢、類別完成,以及威斯康卡片排序測試的持續性錯誤呈相關性。眨眼率的增加也與病前的類精神分裂人格異常和分裂性人格障礙特徵相關。以上相關性都是顯著的。
結論:多巴胺系統的運作或影響病情復發和認知功能,從而改變患者的眨眼率。 Copyright © 2010 Hong Kong College of Psychiatrists.
Original language | English |
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Pages (from-to) | 174-179 |
Journal | East Asian Archives of Psychiatry |
Volume | 20 |
Issue number | 4 |
Publication status | Published - Dec 2010 |
Citation
Chan, K. K. S., Hui, C. L. M., Lam, M. M. L., Tang, J. Y. M., Wong, G. H. Y., Chan, S. K. W., & Chen, E. Y. H. (2010). A three-year prospective study of spontaneous eye-blink rate in first-episode schizophrenia: Relationship with relapse and neurocognitive function. East Asian Archives of Psychiatry, 20(4), 174-179.Keywords
- Blinking
- Cognition
- Dopamine
- Recurrence
- Schizophrenia
- 眨眼
- 認知
- 多巴胺
- 復發
- 精神分裂症
- Alt. title: 首發精神分裂症患者自發性眨眼率的三年前瞻性研究:病情復發和神經認知功能之關係