A randomized controlled neurophysiological study of a Chinese chan-based mind-body intervention in patients with major depressive disorder

Agnes S. CHAN, Yvonne Ming Yee HAN, Sophia L. SZE, Queenie Y. WONG, Mei-chun CHEUNG

Research output: Contribution to journalArticles

17 Citations (Scopus)

Abstract

Our previous studies have reported the therapeutic effects of 10-session Chinese Chan-based Dejian mind-body interventions (DMBI) in reducing the intake of antidepressants, improving depressive symptoms, and enhancing the attentional abilities of patients with depression. This study aims to explore the possible neuroelectrophysiological mechanisms underlying the previously reported treatment effects of DMBI in comparison with those of cognitive behavioral therapy (CBT). Seventy-five age-, gender-, and education-matched participants with depression were randomly assigned to receive either CBT or DMBI or placed on a waitlist. Eyes-closed resting EEG data were obtained individually before and after 10 weeks. After intervention, the DMBI group demonstrated significantly enhanced frontal alpha asymmetry (an index of positive mood) and intra- and interhemispheric theta coherence in frontoposterior and posterior brain regions (an index of attention). In contrast, neither the CBT nor the waitlist group showed significant changes in EEG activity patterns. Furthermore, the asymmetry and coherence indices of the DMBI group were correlated with self-reported depression severity levels and performance on an attention test, respectively. The present findings provide support for the effects of a Chinese Chan-based mind-body intervention in fostering human brain states that can facilitate positive mood and an attentive mind. Copyright © 2013 Agnes S. Chan et al.
Original languageEnglish
Article number812096
JournalEvidence-based Complementary and Alternative Medicine
Volume2013
DOIs
Publication statusPublished - 2013

Citation

Chan, A. S., Han, Y. M. Y., Sze, S. L., Wong, Q. Y., & Cheung, M.-c. (2013). A randomized controlled neurophysiological study of a Chinese chan-based mind-body intervention in patients with major depressive disorder. Evidence-based Complementary and Alternative Medicine, 2013, art no. 812096.

Fingerprint Dive into the research topics of 'A randomized controlled neurophysiological study of a Chinese chan-based mind-body intervention in patients with major depressive disorder'. Together they form a unique fingerprint.