A pilot randomized, controlled study of nanocrystalline silver, manuka honey, and conventional dressing in healing diabetic foot ulcer

Ka-Kit TSANG, Enid Wai-Yung KWONG, Tony Shing-Shun TO, Wai Yee Joanne CHUNG, Kwok Shing Thomas WONG

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11 Citations (Scopus)

Abstract

Nanocrystalline silver (nAg) and Manuka honey (MH) dressing have increasing popularity for treating diabetic foot ulcer (DFU). This study was an open-label randomized controlled trial with three parallel groups' design in examining the preliminary effectiveness of nAg against MH and conventional dressing in healing DFU in terms of ulcer healing, ulcer infection, and inflammation. 31 participants (11 in the nAg group, 10 in the MH group, and 10 in the convention group) diagnosed with type 2 diabetes were enrolled. Wound cleaning, debridement, and topical dressing application were performed according to the group allocation in each visit at weeks 1, 2, 3, 4, 6, 8, 10, and 12. The results found that the proportions of complete ulcer healing were 81.8%, 50%, and 40% in the nAg, MH, and conventional groups, respectively. The ulcer size reduction rate was potentially higher in the nAg group (97.45%) than the MH group (86.21%) and the conventional group (75.17%). In bacteriology, nAg showed a greater rate of microorganism reduction although it was not significant. To conclude, nAg alginate was potentially superior to MH and conventional dressing in healing diabetic foot ulcer in terms of ulcer size reduction rate. Copyright © 2017 Ka-Kit Tsang et al.
Original languageEnglish
Article number5294890
JournalEvidence-based Complementary and Alternative Medicine
Volume2017
DOIs
Publication statusPublished - Jan 2017

Citation

Tsang, K.-K., Kwong, E. W.-Y., To, T. S.-S., Chung, J. W.-Y., & Wong, T. K.-S. (2017, January). A pilot randomized, controlled study of nanocrystalline silver, manuka honey, and conventional dressing in healing diabetic foot ulcer. Evidence-based Complementary and Alternative Medicine, 2017. Retrieved from http://dx.doi.org/10.1155/2017/5294890

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