A comparative multimodal meta-analysis of anisotropy and volume abnormalities in white matter in people suffering from bipolar disorder or schizophrenia

Guorui ZHAO, Kwok Wai LAU, Chanyu WANG, Haifeng YAN, Chichen ZHANG, Kangguang LIN, Shijun QIU, Ruiwang HUANG, Ruibin ZHANG

Research output: Contribution to journalArticlespeer-review

Abstract

Schizophrenia (SZ) and bipolar disorder (BD) share some similarities in terms of genetic-risk genes and abnormalities of gray-matter structure in the brain, but white matter (WM) abnormalities have not been studied in depth. We undertook a comparative multimodal meta-analysis to identify common and disorder-specific abnormalities in WM structure between SZ and BD. Anisotropic effect size-signed differential mapping software was used to conduct a comparative meta-analysis of 68 diffusion tensor imaging (DTI) and 34 voxel-based morphometry (VBM) studies comparing fractional anisotropy (FA) and white matter volume (WMV), respectively, between patients with SZ (DTI: N = 1543; VBM: N = 1068) and BD (DTI: N = 983; VBM: N = 518) and healthy controls (HCs). The bilateral corpus callosum (extending to the anterior and superior corona radiata) showed shared decreased WMV and FA in SZ and BD. Compared with BD patients, SZ patients showed remarkable disorder-specific WM abnormalities: decreased FA and increased WMV in the left cingulum, and increased FA plus decreased WMV in the right anterior limb of the internal capsule. SZ patients showed more extensive alterations in WM than BD cases, which may be the pathophysiological basis for the clinical continuity of both disorders. The disorder-specific regions in the left cingulum and right anterior limb of the internal capsule provided novel insights into both disorders. Our study adds value to further understanding of the pathophysiology, classification, and differential diagnosis of SZ and BD. Copyright © 2021 The Author(s).
Original languageEnglish
Article numbersbab093
JournalSchizophrenia Bulletin
Early online date10 Aug 2021
DOIs
Publication statusE-pub ahead of print - 10 Aug 2021

Citation

Zhao, G., Lau, W. K. W., Wang, C., Yan, H., Zhang, C., Lin, K., . . . Zhang, R. (2021). A comparative multimodal meta-analysis of anisotropy and volume abnormalities in white matter in people suffering from bipolar disorder or schizophrenia. Schizophrenia Bulletin. Advance online publication. doi: 10.1093/schbul/sbab093

Keywords

  • Bipolar disorder
  • Diffusion tensor imaging
  • Schizophrenia
  • Voxel-based morphometry
  • White matter microstructure
  • Fiber crossing

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