3D Dissimilar-Siamese-U-Net for hyperdense middle cerebral artery sign segmentation

Jia YOU, Leung Ho Philip YU, Anderson C.O. TSANG, Eva L.H. TSUI, Paulin P.S. WOO, Carrie S.M. LUI, Gilberto K.K. LEUNG, Neeraj MAHBOOBANI, Chi-yeung CHU, Wing-ho CHONG, Wai-lun POON

Research output: Contribution to journalArticlespeer-review

5 Citations (Scopus)


The hyperdense middle cerebral artery sign (HMCAS) representing a thromboembolus has been declared as a vital CT finding for intravascular thrombus in the diagnosis of acute ischemia stroke. Early recognition of HMCAS can assist in patient triage and subsequent thrombolysis or thrombectomy treatment. A total of 624 annotated head non-contrast-enhanced CT (NCCT) image scans were retrospectively collected from multiple public hospitals in Hong Kong. In this study, we present a deep Dissimilar-Siamese-U-Net (DSU-Net) that is able to precisely segment the lesions by integrating Siamese and U-Net architectures. The proposed framework consists of twin sub-networks that allow inputs of left and right hemispheres in head NCCT images separately. The proposed Dissimilar block fully explores the feature representation of the differences between the bilateral hemispheres. Ablation studies were carried out to validate the performance of various components of the proposed DSU-Net. Our findings reveal that the proposed DSU-Net provides a novel approach for HMCAS automatic segmentation and it outperforms the baseline U-Net and many state-of-the-art models for clinical practice. Copyright © 2021 Published by Elsevier Ltd.
Original languageEnglish
Article number101898
JournalComputerized Medical Imaging and Graphics
Early online date14 Mar 2021
Publication statusPublished - Jun 2021


You, J., Yu, P. L. H., Tsang, A. C. O., Tsui, E. L. H., Woo, P. P. S., Lui, C. S. M., . . . Poon, W.-L. (2021). 3D Dissimilar-Siamese-U-Net for hyperdense middle cerebral artery sign segmentation. Computerized Medical Imaging and Graphics, 90. Retrieved from https://doi.org/10.1016/j.compmedimag.2021.101898


  • Acute ischemic stroke
  • Hyperdense middle cerebral artery sign
  • Segmentation
  • Deep learning


Dive into the research topics of '3D Dissimilar-Siamese-U-Net for hyperdense middle cerebral artery sign segmentation'. Together they form a unique fingerprint.